The Edmond Sun


March 14, 2006

Local diabetes research proves enlightening

EDMOND — A study by researchers at the University of Oklahoma Health Sciences Center is shedding new light on how diabetes affects the body.

Dr. Michael Ihnat, an assistant professor of cell biology and director of the medical pharmacology course at the OUHSC, has completed research showing cells actually have a “memory” of the stress brought on by high glucose levels, a hallmark of diabetes.

Ihnat, along with researchers in Italy and Hungary, have found that cells remained stressed, even after the glucose levels in the cells returned to normal.

“In addition to understanding what causes changes in insulin and glucose in the diabetic patient, we have to understand how high glucose damages normal tissue,” Ihnat said. “If we can better understand it, we can help prevent the damage this (diabetes) causes the patient.”

The first phase of the study began with endothelial cells, those cells that line the blood vessels, growing in Petri dishes. For two weeks, researchers exposed the cells to high levels of glucose. Then for one week they normalized the glucose levels.

Yet, the cells remained just as stressed as they had been in high glucose levels for the entire time, even when glucose levels returned to normal, Ihnat said.

The researchers moved on to tests involving those organs commonly affected by diabetes — the retina of the eye and the kidneys. Again, the organs remained stressed even after one week of normal glucose levels.

Next, Ihnat began to look at what was perpetuating this cellular memory and what could be done to interrupt it. When antioxidants were added after glucose levels were made normal, the team found the memory was indeed interrupted.

In fact, by adding a-lipoic acid, a common antioxidant that can be purchased at many health food stores and drug store chains, the cycle of stress seemed to break, Ihnat said.

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